lipopolysaccharide
(noun)
any of a large class of lipids conjugated with polysaccharides
Examples of lipopolysaccharide in the following topics:
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Gram-Negative Outer Membrane
- The outer membrane of Gram-negative bacteria invariably contains a unique component, lipopolysaccharide (LPS) in addition to proteins and phospholipids.
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Antimicrobial Peptides
- These peptides qualify as innovative drugs that might be used as antibiotics, anti-lipopolysaccharide drugs, or modifiers of inflammation reactions.
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Pathogenic Escherichia coli
- Pathogenic E. coli strains can be categorized based on elements that can elicit an immune response in animals, namely: O antigen, K antigen, H antigen, and F antigen in the lipopolysaccharide (LPS) molecules found in the outer membrane of the E. coli cell.
- Structure of a lipopolysaccharide showing the O antigen, core region and lipid A.
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Batch Culture of Bacteriophages
- To enter a host cell, bacteriophages attach to specific receptors on the surface of bacteria, including lipopolysaccharides, teichoic acids, proteins, or even flagella.
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Fusobacteria
- However, in contrast to Bacteroides, Fusobacterium have a potent lipopolysaccharide that can function as an endotoxin.
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Overview of Proteobacteria
- All proteobacteria are Gram-negative, with an outer membrane mainly composed of lipopolysaccharides.
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Polysaccharide Biosynthesis
- UDP-glucose can also be used as a precursor of lipopolysaccharides, and peptidoglycan.
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Basic Structures of Prokaryotic Cells
- Gram-negative bacteria have a relatively thin cell wall composed of a few layers of peptidoglycan (only 10 percent of the total cell wall), surrounded by an outer envelope containing lipopolysaccharides (LPS) and lipoproteins.
- In gram-negative bacteria, the cell wall is surrounded by an outer membrane that contains lipopolysaccharides and lipoproteins.
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Fever
- Exogenous factors include a variety, such as lipopolysaccharide toxin (from gram negative bacteria) which can activate a number of innate immune activation pathways.
- For example, if an NK cell detects lipopolysaccharide from a pathogen, it will release TNFα, which will travel through the bloodstream to induce a number of long-lasting inflammatory changes, including fever.
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Lipid Biosynthesis
- Many of the immune activating abilities of lipopolysaccharide can be attributed to the lipid A unit.