Examples of epitope in the following topics:
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- Antigen epitopes make it possible for the immune system to recognize pathogens.
- In antibodies, the binding site for an epitope is called a paratope.
- Although epitopes are usually derived from non-self proteins, sequences derived from the host that can be recognized are also classified as epitopes.
- Epitopes determine how antigen binding and antigen presentation occur.
- Most epitopes are conformational.
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- Monoclonal antibodies are monospecific antibodies that recognize one specific epitope on a pathogen.
- Monoclonal antibodies have monovalent affinity in that they bind to the same epitope.
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- Any such distinct molecular feature constitutes an epitope.
- Therefore, most antigens have the potential to be bound by several distinct antibodies, each of which is specific to a particular epitope.
- Using the "lock and key" metaphor, the antigen itself can be seen as a string of keys - any epitope being a "key" - each of which can match a different lock.
- Different antibody idiotypes, each having distinctly formed complementarity determining regions, correspond to the various "locks" that can match "the keys" (epitopes) presented on the antigen molecule.
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- Humans generate an estimated 10 billion different antibodies, each capable of binding a distinct antigen epitope.
- A group of antibodies can be called monovalent (or specific) if they have affinity for the same epitope, or for the same antigen (but potentially different epitopes on the molecule), or for the same strain of microorganism (but potentially different antigens on or in it).
- In contrast, monoclonal antibodies are monovalent for the same epitope.
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- All B cells derive from a particular cell, and thus, the antibodies their differentiated progenies produce can recognize and/or bind the same specific surface components composed of biological macromolecules (epitope) of a given antigen.
- Most of such B cells differentiate into plasma cells that secrete antibodies into blood that bind the same epitope that elicited proliferation in the first place.
- A small minority survives as memory cells that can recognize only the same epitope.
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- If the antibodies recognize their epitope on the MHC, then complement activation occurs and the cell will be osmotically lysed.
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- In this case, the hapten acts as the epitope for the antigen, which binds to the antibodies without causing a response.
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- Streptococcal M protein and coxsackievirus B have regions (epitopes) that are immunologically similar to cardiac myosin.
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- Each tip of the "Y" of an antibody contains a paratope (a structure analogous to a lock) that is specific for one particular epitope (similarly analogous to a key) on an antigen, allowing these two structures to bind together with precision.
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- Here, the body's own epitopes are presented to the infant lymphocytes; those that react are recognized as auto-reactive and destroyed before they (and their future cloned daughter cells) can leave and wreak havoc in the body.