Examples of protease in the following topics:
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- Protease inhibitors target viral proteases which are key enzymes for the completion of viral maturation.
- Proteases are enzymes that have the ability to cut proteins into peptides.
- Natural protease inhibitors are found in Shiitake mushrooms.
- Some protease inhibitors do not mimic peptides in their structure.
- It is one of the major drawbacks of protease inhibitors therapy.
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- Polypeptides are commonly broken down via hydrolysis of the peptide bonds by utilizing a class of enzymes called proteases.
- The lysosome contains proteases that are able to target and degrade proteins.
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- Proteases are used by biscuit manufacturers to lower the protein level of flour.
- Amylase, glucanases, and proteases are used to split polysaccharides and proteins in the malt.
- Proteases are used to remove cloudiness produced during storage of beers.
- In the production of biological detergents, proteases, produced in an extracellular form from bacteria, are used in pre-soak conditions and direct liquid applications, helping with the removal of protein stains from clothes.
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- There, it is cleaved by HIV protease and processed into the two HIV envelope glycoproteins, gp41 and gp120.
- During maturation, HIV proteases cleave the polyproteins into individual functional HIV proteins.
- This cleavage step can be inhibited by protease inhibitors.
- Steps in the HIV Replication Cycle: Fusion of the HIV cell to the host cell surface.Cell Entry, HIV RNA, reverse transcriptase, integrase, and other viral proteins enter the host cell.Viral DNA is formed by reverse transcription.Viral DNA is transported across the nucleus and integrates into the host DNA.New viral RNA is used as genomic RNA to make viral proteins.New viral RNA and proteins move to cell surface and a new, immature, HIV virus forms.Virus maturation and protease release of individual HIV proteins.
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- This light chain is an enzyme (a protease) that attacks one of the fusion proteins (SNAP-25, syntaxin or synaptobrevin) at a neuromuscular junction, preventing vesicles from anchoring to the membrane to release acetylcholine.
- The light chain of the toxin has protease activity.
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- After HIV has bound to the target cell, the HIV RNA and various enzymes (including reverse transcriptase, integrase, ribonuclease, and protease) are injected into the cell.
- Steps in the HIV Replication Cycle: Fusion of the HIV cell to the host cell surface.Cell Entry, HIV RNA, reverse transcriptase, integrase, and other viral proteins enter the host cell.Viral DNA is formed by reverse transcription.Viral DNA is transported across the nucleus and integrates into the host DNA.New viral RNA is used as genomic RNA to make viral proteins.New viral RNA and proteins move to cell surface and a new, immature, HIV virus forms.Virus maturation and protease release of individual HIV proteins.
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- In addition to being fused to an integral membrane protein, the Cub moiety is also fused to a transcription factor (TF) that can be cleaved off by ubiquitin specific proteases.
- The reconstituted split-ubiquitin molecule is recognized by ubiquitin specific proteases, which cleave off the reporter protein, allowing it to induce the transcription of reporter genes.
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- They also shuttle proteins from one compartment to another inside the cell and target old or terminally misfolded proteins to proteases for degradation.
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- Inbetween the 5' and 3' region is the protein encoding region of the retrovirus, consisting of gag proteins, protease (PR), pol proteins and env proteins.
- Protease is expressed differently in different viruses.
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- When stimulated by one of several triggers, proteases in the system cleave specific proteins to release cytokines and initiate an amplifying cascade of further cleavages.
- The three pathways of activation all generate homologous variants of the protease C3-convertase.