prion

Examples of prion in the following topics:

• Prions

  • The word prion, coined in 1982 by Stanley B.
  • When a prion enters a healthy organism, it induces existing, properly folded proteins to convert into the disease-associated prion form; it acts as a template to guide the misfolding of more proteins into prion form.
  • All known mammalian prion diseases are caused by the so-called prion protein, PrP.
  • Proteins showing prion-type behavior are also found in some fungi, which has been useful in helping to understand mammalian prions.
  • However, a model of prion replication must explain both how prions propagate, and why their spontaneous appearance is so rare.

• Variant Creutzfeldt-Jakob Disease

  • Variant Creutzfeldt–Jakob Disease (vCJD) is a fatal neurological disorder which is caused by prions.
  • This is due to a type of infectious protein called a prion .
  • Transmissible spongiform encephalopathy diseases are caused by prions.
  • Thus, the diseases are sometimes called prion diseases.
  • The brown staining is for the prion protein responsible for variant Creutzfeldt–Jakob disease prion.

• Intracellular Pathogens

  • A pathogen or infectious agent is a microorganism such as a virus, bacterium, prion, or fungus that causes disease in its host.
  • A pathogen or infectious agent is a microorganism such as a virus, bacterium, prion, or fungus that causes disease in its host.
  • According to the prion theory, prions are infectious pathogens that do not contain nucleic acids.
  • Although prions fail to meet the requirements laid out by Koch's postulates, the hypothesis of prions as a new class of pathogen led Stanley B.
  • Stanley Prusiner discovered prions, which are a class of infectious self-reproducing pathogens primarily or solely composed of protein.

• Bovine Spongiform Encephalopathy

  • The infectious agent in BSE is believed to be a specific type of misfolded protein called a prion.
  • Prions will not disappear even if the beef containing them is cooked.
  • Prion proteins carry the disease between individuals and cause deterioration of the brain.
  • In the brain, these proteins cause native cellular prion protein to deform into the infectious state, which then goes on to deform further prion protein in an exponential cascade.
  • Different hypotheses exist for the origin of prion proteins in cattle.

• Defective Viruses

  • prions (proteins that can exist in a pathological conformation that induces other prion molecules to assume that same conformation)

• Basic Microbiology

  • Viruses and prions, though not strictly classed as living organisms, are also studied.

• Exceptions to Koch's Postulates

  • The second postulate may also be suspended for certain microorganisms or entities that cannot (at the present time) be grown in pure culture, such as prions responsible for Creutzfeldt–Jakob disease.

• T Cell Receptors

• Filtration

  • Some studies have shown that prions can be removed or reduced by filtration.

• The Diagnostic Scheme

  • The images are useful in detection of, for example, a bone abscess or a spongiform encephalopathy produced by a prion.