cytolytic

Examples of cytolytic in the following topics:

• Classes of T Cells

  • Effector cells include helper T cells, and cytolytic or cytotoxic T cells.
  • Cytolytic or cytotoxic T cells (characterized by the expression of CD8 marker on their surface) kill cells that produce foreign antigens, such as cells infected by viruses and other intracellular microbes .

• T Cell Receptors

  • The antigen receptor of MHC-restricted CD4 helper T cells and CD8 cytolytic T cell is a heterodimer consisting of two transmembrane polypeptide chains, designated alpha and beta, covalently linked to each other by disulfide bonds.

• Natural Killer Cells

  • NK cells use two cytolytic granule mediated apoptosis to destroy abnormal and infected cells.
  • Antibodies that bind to antigens can be recognized by FcϒRIII (CD16) receptors (a type of activating receptor), resulting in NK activation, release of cytolytic granules, and consequent cell apoptosis.

• Natural Killer Cells

  • NK cells paralyze target cells using the cytolytic protein perforin and a variety of protease enzymes.
  • Functions of NK cells include: Cytolytic Granule Mediated Cell Apoptosis; Antibody-Dependent Cell-Mediated Cytotoxicity (ADCC); Cytokine induced NK and CTL activation; Missing 'self' hypothesis; Tumor cell surveillance; NK cell function in adaptive response; NK cell function in pregnancy; and NK cell evasion by tumor cells .

• Interferons

  • As an infected cell dies from a cytolytic virus, viral particles are released that can infect nearby cells.

• The Complement System

  • MAC is the cytolytic endproduct of the complement cascade; it forms a transmembrane channel, which causes osmotic lysis of the target cell.

• Specific T-Cell Roles

  • ., cytokine production and release of cytolytic/cell killing molecules).