Examples of Plasmin in the following topics:
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- The main enzyme in primary fibrinolysis is plasmin, a proteolytic enzyme that degrades fibrin mesh.
- Plasmin is produced in an inactive form, plasminogen, in the liver.
- Instead, it is incorporated into the clot when it is formed and then activated into plasmin later.
- In contrast, plasmin further stimulates plasmin generation by producing more active forms of both tissue plasminogen activator (tPA) and urokinase.
- Alpha 2-antiplasmin and alpha 2-macroglobulin inactivate plasmin.
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- Normally, anticoagulants and fibrinolytics in the plasma, such as plasmin and heparin, break up fibrin clots and inactivate thrombin.
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- Plasmin: generated by proteolytic cleavage of plasminogen, a potent fibrinolytic that degrades fibrin and destroys clots.