Examples of overloading in the following topics:
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- Iron overload, also known as hemochromatosis, is an accumulation of iron in the body and can lead to tissue and organ damage.
- Ted DeVita, the "bubble boy," died of transfusional iron overload from too many blood transfusions.
- In medicine, iron overload indicates accumulation of iron in the body from any cause.
- Typical treatment for chronic iron overload requires subcutaneous injection over a period of 8–12 hours daily.
- Discuss the causes of iron overload and the resulting tissue damage
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- Sustained, repeated overload of a muscle group leads to hypertrophy and strengthening of those muscles.
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- Among the causes of spasms are insufficient hydration, muscle overloading, and an absence of electrolytes.
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- Patellofemoral pain syndrome may also result from overuse or overload of the PF joint.
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- Most shin splints, known as Medial Tibial Stress Syndrome (MTSS), can be attributed to overloading the muscles of the lower extremities or biomechanical irregularities.
- Increasing activity, intensity, and duration too quickly leads to shin splints because the tendons and muscles are unable to absorb the impact of the shock force as they become fatigued; also, the tibial bone-remodeling capabilities are overloaded.
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- The chronic development of pulmonary edema may be associated with symptoms and signs of "fluid overload," this is a non specific term to describe the manifestations of left ventricular failure on the rest of the body and includes peripheral edema (swelling of the legs, in general, of the "pitting" variety, wherein the skin is slow to return to normal when pressed upon), raised jugular venous pressure and hepatomegaly, where the liver is enlarged and may be tender or even pulsatile.
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- The pericardium lubricates the heart and prevents it from becoming too large if blood volume is overloaded (though it will not prevent chronic heart enlargement).
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- Whole blood is not used because the extra plasma can contribute to transfusion associated circulatory overload (TACO), a potential complication that can dangerously increase blood pressure, causing pulmonary edema and acute respiratory distress.
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- Lung injury is common as well, due to pulmonary edema from fluid overload if plasma volume becomes too high or neutrophil activation during a transfusion reaction.
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- Overloading of muscles damages these connections and the orientation of the contractile filaments.