integrin

(noun)

Is a transmembrane receptor that mediates the attachment between a cell and the tissues that surround it, such as other cells or the extracellular matrix (ECM).

Related Terms

Examples of integrin in the following topics:

  • Hemidesmosomes

    • An example configuration of a hemidesmosome might consist of cytosolic keratin, non-covalently bonded to a cytosolic plectin plaque, which is bonded to a single-pass transmembrane adhesion molecule such as the α6β4 integrin.
    • The integrin might then attach to one of many multi-adhesive proteins such as laminin, resident within the extracellular matrix, thereby forming one of many potential adhesions between cell and matrix.

  • Basement Membranes and Diseases

    • It is caused by a mutation in the integrin α6β4 cell-adhesion molecule on either the alpha or beta subunit.

  • Inflammation

    • Then, integrins will firmly attach to the adhesion molecules on the endothelial cells, which is called adhesion.

  • Development of the Immune System

    • This is due to lower opsonic activity, as well as diminished up-regulation of integrin and selectin receptors, which limit the ability of neutrophils to interact with adhesion molecules in the endothelium.

  • Mammary Glands

    • Laminin and collagen in myoepithelial basement membrane interacting with beta-1 integrin on epithelial surface again, is essential in this process.