megakaryocyte

Examples of megakaryocyte in the following topics:

• Platelet Formation

  • Platelets are membrane-bound cell fragments derived from megakaryocytes, which are produced during thrombopoiesis.
  • Platelets are small, clear, irregularly-shaped cell fragments produced by larger precursor cells called megakaryocytes.
  • Megakaryocyte and platelet production is regulated by thrombopoietin, a hormone produced by the liver and kidneys.
  • Each megakaryocyte produces between 5,000 and 10,000 platelets before its cellular components are fully depleted.
  • Myeloid progenitor cells differentiate into promegakaryocytes, and megakaryocytes, which release platelets.

• Platelets and Coagulation Factors

  • Small cell fragments called platelets (thrombocytes) are formed from the disintegration of larger cells called megakaryocytes ( a).
  • For each megakaryocyte, 2000–3000 platelets are formed with 150,000 to 400,000 platelets present in each cubic millimeter of blood.
  • (a) Platelets are formed from large cells called megakaryocytes.
  • The megakaryocyte breaks up into thousands of fragments that become platelets.

• Platelets

  • Platelets, also called thrombocytes, are membrane-bound cell fragments derived from the fragmentation of larger precursor cells called megakaryocytes, which are derived from stem cells in the bone marrow.
  • Platelets are not true cells, but are instead classified as cell fragments produced by megakaryocytes.
  • However, they do contain mitochondria and mitochondrial DNA, as well as endoplasmic reticulum fragments and granules from the megakaryocyte parent cells.

• Development of Blood

  • Myelocytes, which include granulocytes, megakaryocytes, and macrophages, are derived from common myeloid progenitors and are involved in such diverse roles as innate immunity, adaptive immunity, and blood clotting.
  • On the other hand, thrombopoietin makes myeloid progenitor cells differentiate to megakaryocytes, which produce platelets.

• Development of Blood and Blood Vessels

  • Hematopoietic stem cells can of course undergo self-renewal, and are multipotent cells that give rise to erythrocytes (red blood cells), megakaryocytes/platelets, mast cells, T-lymphocytes, B-lymphocytes, dendritic cells, natural killer cells, monocyte/macrophage, and granulocytes.

• Medical Uses of Hematopoietic Growth Factors

  • Trials of a modified recombinant form, megakaryocyte growth and differentiation factor (MGDF), were stopped when healthy volunteers developed autoantibodies to endogenous thrombopoietin and then developed thrombocytopenia themselves.

• Components of Blood

  • They result from fragmentation of large cells called megakaryocytes, which are derived from stem cells in the bone marrow.

• WBC Formation

  • Megakaryocytes (the cells that produce platelets) and erythrocytes (red blood cells) are not formally considered to be leukocytes, but arise from the common myeloid progenitor cells that produce the other cellular components of blood.