integrin

Examples of integrin in the following topics:

• Hemidesmosomes

  • An example configuration of a hemidesmosome might consist of cytosolic keratin, non-covalently bonded to a cytosolic plectin plaque, which is bonded to a single-pass transmembrane adhesion molecule such as the α6β4 integrin.
  • The integrin might then attach to one of many multi-adhesive proteins such as laminin, resident within the extracellular matrix, thereby forming one of many potential adhesions between cell and matrix.

• HIV Attachment and Host Cell Entry

  • The HIV coat protein, gp120, binds to integrin α4β7, activating LFA-1 (the central integrin involved in the establishment of bridges known as "virological synapses") which facilitate efficient cell-to-cell spreading of HIV-1.

• Planctomycetes

  • One such example is a gene sequence (in Gemmata obscuriglobus) that was found to have significant homology to the integrin alpha-V, a protein that is important in transmembrane signal transduction in eukaryotes.

• Basement Membranes and Diseases

  • It is caused by a mutation in the integrin α6β4 cell-adhesion molecule on either the alpha or beta subunit.

• Double-Stranded DNA Viruses: Adenoviruses

  • Next, a specialized motif in the penton base protein interacts with αv integrin, stimulating internalization of the adenovirus via clathrin-coated pits, resulting in entry of the virion into the host cell within an endosome.

• Development of the Immune System

  • This is due to lower opsonic activity, as well as diminished up-regulation of integrin and selectin receptors, which limit the ability of neutrophils to interact with adhesion molecules in the endothelium.

• Fluid Mosaic Model

  • Integral proteins (some specialized types are called integrins) are, as their name suggests, integrated completely into the membrane structure, and their hydrophobic membrane-spanning regions interact with the hydrophobic region of the the phospholipid bilayer .

• Inflammation

  • Then, integrins will firmly attach to the adhesion molecules on the endothelial cells, which is called adhesion.

• Mammary Glands

  • Laminin and collagen in myoepithelial basement membrane interacting with beta-1 integrin on epithelial surface again, is essential in this process.