induced fit

(noun)

Proposes that the initial interaction between enzyme and substrate is relatively weak, but that these weak interactions rapidly induce conformational changes in the enzyme that strengthen binding.

Related Terms

Examples of induced fit in the following topics:

  • Enzyme Active Site and Substrate Specificity

    • This model asserted that the enzyme and substrate fit together perfectly in one instantaneous step.
    • However, current research supports a more refined view called induced fit .
    • According to the induced fit model, both enzyme and substrate undergo dynamic conformational changes upon binding.

  • Enzyme Catalysis

    • One model of enzyme mechanism is called the induced fit model.

  • Ecology, Epidemiology, and Evolution of Pathogens

    • One definition of this is the host's parasite-induced loss of fitness.
    • The parasite's fitness is determined by its success in transmitting its offspring to other hosts.
    • This might induce faster host death, and act against the parasite's fitness by reducing probability to encounter another host (killing the host too fast to allow for transmission).
    • The idea is then, that there exists an equilibrium point of virulence, where parasite's fitness is highest.
    • Any movement on the virulence axis, towards higher or lower virulence, will result in lower fitness for the parasite, and this will be selected against.

  • Voluntary, Involuntary, and Trust Associations

    • A second type of association, which we will call trusts, is created by unilaterally conferring inducements.
    • Voluntary associations, a third type, are created by the exchange or transfer of inducements or expected inducements by mutual consent.
    • Traditional difficulties fitting the family into general social analysis may derive from its two dimensionality.
    • The fourth combination of types—sanctions by mutual consent—can exist only when sanctions are falsely expected to be inducements by the party who consents to them.
    • Hence, the definition of voluntary associations is in terms of inducements or expected inducements.

  • Regulating Virulence

    • In an ecological context, virulence can be defined as the host's parasite-induced loss of fitness.
    • This is because the fitness of the host is bound to the fitness in vertical transmission but is not so bound in horizontal transmission.The pathogen population can evolve once it is in the host .

  • Mutation

    • They can also be induced by the organism itself, through cellular processes such as hypermutation.
    • The distribution of fitness effects of mutations in vesicular stomatitis virus.
    • The fitness of each mutant was compared with the ancestral type.
    • A fitness of zero, less than one, one, more than one, respectively, indicates that mutations are lethal, deleterious, neutral, and advantageous.

  • Alkylidene Reactions

    • A ROMP catalyst, for example, should complex preferentially with the ring double bond, inducing ring cleavage and formation of a new catalytic site.
    • Much effort has been devoted to creating metathesis catalysts with improved binding and turnover characteristics to fit specific transformations.
    • It is fitting that Y.

  • Exercise and Health

    • Exercise is any activity that requires physical effort and is carried out with the goal of sustaining or improving physical fitness.
    • All of these types of physical exercise contribute to physical fitness.
    • They work in conjunction with neurotransmitters to induce relief, happiness, or even euphoria when the body is in pain or overexerted.
    • This phenomenon is due not only to the chemicals involved, but also results from the positive body-image and feeling of competence that come with accomplishing a fitness goal.

  • Inductance

    • Induction is the process in which an emf is induced by changing magnetic flux.
    • See , where simple coils induce emfs in one another.
    • These coils can induce emfs in one another like an inefficient transformer.
    • Here a change in current in coil 1 is seen to induce an emf in coil 2.
    • (Note that "E2 induced" represents the induced emf in coil 2. )

  • Motional EMF

    • Motion in a magnetic field that is stationary relative to the Earth induces motional EMF (electromotive force).
    • When flux changes, an EMF is induced according to Faraday's law of induction.
    • To find the direction of the induced field, the direction of the current, and the polarity of the induced EMF we apply Lenz' law, as explained in Faraday's Law of Induction: Lenz' Law.
    • Thus the induced field must oppose the existing one and be out of the page.
    • (b) Lenz's law gives the directions of the induced field and current, and the polarity of the induced emf.