fibronectin

(noun)

An extra cellular matrix protein, often laid down as a component of the temporary granulation tissue seen in wound healing.

Related Terms

Examples of fibronectin in the following topics:

  • Deep Wound Healing

    • The provisional ECM laid down during the proliferative phase is rich in fibronectin and collagen III that combine to allow quicker cell movement through the wound, which is very important during wound healing.
    • In large, deep wounds the remodelling of a fibronectin and collagen III-rich ECM to a collagen-I rich ECM may not occur, leading to a weakening of the tissue.

  • Microbial Evasion of Phagocytosis

    • Treponema pallidum, the bacterium that causes syphilis, hides from phagocytes by coating its surface with fibronectin, which is produced naturally by the body and plays a crucial role in wound healing.

  • Muscle Development

    • When the FGF runs out, the myoblasts cease division and secrete fibronectin onto their extracellular matrix.

  • Premature Infants

    • Fetal fibronectin has become the most important biomarker.

  • Steps of Tissue Repair

    • Granulation: Fibroblasts attracted to the wound site quickly lay down a temporary extra cellular matrix, comprised of collagen and fibronectin, upon which the epidermis can be reconstituted.