Examples of pyrimidine in the following topics:
-
- Because tetrahydrofolate is essential for purine and pyrimidine synthesis, its deficiency can lead to inhibited production of DNA, RNA and proteins.
- The second type of antimetabolite antibiotics consist of pyrimidine analogues which mimic the structure of metabolic pyrimidines .
- Three nucleobases found in nucleic acids, cytosine (C), thymine (T), and uracil (U), are pyrimidine derivatives and the pyrimidine analogues disrupt their formation and consequently disrupt DNA and RNA synthesis.
- Distinguish between the three main types of antimetabolite antibiotics (antifolates, pyrimidine and purine analogues)
-
- Unlike pyrimidines, purines are biologically synthesized as nucleotides and in particular as ribotides.
- The first three enzymes of pyrimidine biosynthesis are all coded by the same gene in Metazoa.
- CTP synthase (or CTP synthetase) is an enzyme involved in pyrimidine biosynthesis.
- This acts to balance the relative amounts of purine and pyrimidine nucleotides.
- Adenine and guanine are purines and cytosine and thymine are pyrimidines.
-
- Biosynthetic building blocks utilized by organisms include amino acids, purines, pyrimidines, lipids, sugars, and enzyme cofactors.
-
- Uridine-5'-triphosphate (UTP) and cytidine-5'-triphosphate (CTP) (pyrimidine nucleoside triphosphates) are disfavoured at the initiation site.