hemagglutinin

Examples of hemagglutinin in the following topics:

• Replicative Cycle of Influenza A

  • After the hemagglutinin is cleaved by a protease, the cell imports the virus by endocytosis.
  • The hemagglutinin protein fuses the viral envelope with the vacuole's membrane.
  • Hemagglutinin and neuraminidase molecules cluster into a bulge in the cell membrane.
  • The mature virus buds off from the cell in a sphere of the host phospholipid membrane, acquiring hemagglutinin and neuraminidase with this membrane coat (Step 7).
  • Contrast the roles of hemagglutinin and neuraminidase throughout the major stages of the replicative cycle of influenza A virus

• Attachment and Entry to the Host Cell

  • The glycoprotein responsible for attachment on the surface of an influenza viral particle is hemagglutinin (HA).
  • Of special note is HA (hemagglutinin), the glycoprotein critical for influenza attachment and entry into host cells.
  • Explain the role of hemagglutinin in the attachment and entry processes of influenza virus

• Emergence of Viral Pathogens

  • For example, if a pig was infected with a human influenza virus and an avian influenza virus at the same time, an antigenic shift could occur, producing a new virus that had most of the genes from the human virus, but a hemagglutinin or neuraminidase from the avian virus.
  • The resulting new virus would likely be able to infect humans and spread from person to person, but it would have surface proteins (hemagglutinin and/or neuraminidase) not previously seen in influenza viruses that infect humans, and therefore most people would have little or no immune protection.