TCA cycle

(noun)

an alternative name for the Krebs cycle or citric acid cycle

Related Terms

Examples of TCA cycle in the following topics:

  • The Reverse TCA Cycle

    • The reverse TCA cycle utilizes carbon dioxide and water to form carbon compounds.
    • The citric acid cycle (TCA) or Krebs cycle, is a process utilized by numerous organisms to generate energy via the oxidation of acetate derived from carbohydrates, fats, and proteins into carbon dioxide .
    • However, there are numerous organisms that undergo reverse TCA or reverse Krebs cycles.
    • The chemical reactions that occur are the reverse of what is seen in the TCA cycle .
    • The following is a brief overview of the reverse TCA cycle.

  • Acetyl CoA and the Citric Acid Cycle

    • The citric acid cycle, shown in —also known as the tricarboxylic acid cycle (TCA cycle) or the Krebs cycle—is a series of chemical reactions used by all aerobic organisms to generate energy through the oxidation of acetate—derived from carbohydrates, fats, and proteins—into carbon dioxide.
    • The NADH generated by the TCA cycle is fed into the oxidative phosphorylation pathway.
    • Components of the TCA cycle were derived from anaerobic bacteria, and the TCA cycle itself may have evolved more than once.
    • Theoretically there are several alternatives to the TCA cycle, however the TCA cycle appears to be the most efficient.
    • If several alternatives independently evolved, they all rapidly converged to the TCA cycle.

  • Biosynthesis and Energy

    • The major pathways utilized to ensure fixation of carbon dioxide include: the Calvin cycle, the reductive TCA cycle, and the acetyl-CoA pathway.
    • The Calvin cycle involves utilizing carbon dioxide and water to form organic compounds.
    • The reductive TCA cycle, commonly referred to as the reverse Krebs cycle, also produces carbon compounds from carbon dioxide and water.

  • Organic Acid Metabolism

    • The fatty acid chain that is left over after the thiolation step can then reenter the β-oxidation pathway, which can cycle until the fatty acid has been completely reduced to acetyl-CoA.
    • Acertyl-CoA is the entry molecule for the TCA cycle.
    • The TCA cycle is the process used by all aerobic organisms to generate energy .

  • Lipid Metabolism

    • These fatty acids can then enter a dedicated pathway that promotes step-wise lipid processing that ultimately yields acetyl-CoA, a critical metabolite that conveys carbon atoms to the TCA cycle (aka Krebs cycle or citric acid cycle) to be oxidized for energy production.
    • The acetyl-CoA molecule liberated by this process is eventually converted into ATP through the TCA cycle.
    • This cycle repeats until the fatty acid has been completely reduced to acetyl-CoA, which is fed through the TCA cycle to ultimately yield cellular energy in the form of ATP .

  • Acetyl CoA to CO2

    • The acetyl carbons of acetyl CoA are released as carbon dioxide in the citric acid cycle.
    • Acetyl CoA links glycolysis and pyruvate oxidation with the citric acid cycle.
    • The TCA cycle is named for tricarboxylic acids (TCA) because citric acid (or citrate) and isocitrate, the first two intermediates that are formed, are tricarboxylic acids.
    • Additionally, the cycle is known as the Krebs cycle, named after Hans Krebs, who first identified the steps in the pathway in the 1930s in pigeon flight muscle.
    • Describe the fate of the acetyl CoA carbons in the citric acid cycle

  • Substrates for Biosynthesis

    • The citric acid cycle, commonly referred to as the Krebs cycle, is characterized by the production of energy through the oxidation of acetate derived from carbohydrates, fats, and proteins into carbon dioxide.
    • The cycle is one of the major metabolic processes utilized to generate energy.
    • The citric acid cycle, comprised of a series of chemical reactions, provides precursors for additional biochemical pathways.
    • Additional pathways that require precursors formed by the TCA include amino acid and nucleotide synthesis .
    • Additional pathways that require substrates or metabolites produced by the glycolytic pathway include: gluconeogenesis, lipid metabolism, the pentose phosphate pathway, and the TCA.

  • Genital Warts

    • Its use is cycled (2 times per day for 3 days then 4–7 days off); one review states that it should only be used for four cycles.
    • Trichloroacetic acid (TCA) is less effective than cryosurgery, and is not recommended for use in the vagina, cervix, or urinary meatus.

  • The Carbon Cycle

  • Life Cycle of Small Business