prostaglandin

Examples of prostaglandin in the following topics:

• Prostaglandins

  • The prostaglandins are given systematic names that reflect their structure.
  • The initially formed peroxide PGH2 is a common intermediate to other prostaglandins, as well as thromboxanes such as TXA2.

• Nonsteroidal Anti-Inflammatory Drugs

  • NSAIDs prevent the release of prostaglandins that promotes inflammation and fever in the body.
  • NSAIDs prevent certain chemicals in the body that promote the inflammation, fever, and pain, called prostaglandins.
  • The prostaglandins are produced inside the body's cells and can alter the functions of cells in the body.
  • It produces the prostaglandins that line the stomach and protects it from acids and other digestive chemicals, which can sometimes lead to the bleeding of the stomach lining.
  • The NSAIDs inhibit both the enzymes and prevent the large production of the prostaglandins in the body.

• Peptic Ulcer Disease

  • The gastric mucosa protects itself from gastric acid with a layer of mucus, the secretion of which is stimulated by certain prostaglandins.
  • NSAIDs block the function of cyclooxygenase 1 (cox-1), which is essential for the production of these prostaglandins.
  • Patients who are taking NSAIDs may also be prescribed a prostaglandin analogue in order to help prevent peptic ulcers by replacing the prostaglandins whose formation is blocked by NSAID use.

• Fever

  • Fever is an elevation of body temperature above the regulatory set point, mediated through the release of prostaglandin E2.
  • The primary fever mediator in the human body is prostaglandin E2 (PGE2), which acts on the hypothalamus to raise the temperature set point.
  • This pathway is mediated by the enzymes phospholipase A2 (PLA2), cyclooxygenase-2 (COX-2), and prostaglandin E2 synthase.

• Fatty Acids

  • These acids are also precursors to the prostaglandins, a family of physiologically potent lipids present in minute amounts in most body tissues.

• Eicosanoids

• Hair and Hormones

  • Recent research suggests that elevated levels of the enzyme prostaglandin D2 synthase and its product prostaglandin D2 (PGD2) in hair follicles contribute to androgenetic alopecia.

• Abortion

  • Medical abortion became an alternative method of abortion with the availability of prostaglandin analogs in the early 1970s and the antiprogestogen mifepristone in the 1980s.
  • Premature labor and delivery can be induced with prostaglandin; this can be coupled with injecting the amniotic fluid with hypertonic solutions containing saline or urea.

• Fetal Circulation

  • Additionally, the increase in the concentration of oxygen in the blood leads to a decrease in prostaglandins, causing closure of the ductus arteriosus.

• Labor and Birth

  • At the same time, the placenta releases prostaglandins into the uterus, increasing the contractions.