pluripotent

Examples of pluripotent in the following topics:

• Cellular Differentiation

  • These cells are referred to as pluripotent.
  • Pluripotent stem cells undergo further specialization into multipotent progenitor cells that then give rise to functional cells.

• Gene Expression in Stem Cells

  • The pathway that is taken to produced specialized cells included: the embryonic cells develop from totipotent cells, to pluripotent cells which undergo differentiation and become more specialized.
  • Asymmetric division of stem cells plays a key role in development by allowing for the differentiation of a subset of daughter cells while maintaining stem cell pluripotency.
  • Pluripotent, embryonic stem cells originate as inner cell mass (ICM) cells within a blastocyst.

• Mechanics of Cellular Differentation

  • The embryonic cells that develop from totipotent stem cells and are precursors to the fundamental tissue layers of the embryo are classified as pluripotent.
  • A pluripotent stem cell is one that has the potential to differentiate into any type of human tissue but cannot support the full development of an organism.

• Development of Blood and Blood Vessels

  • They are multipotent, which describes the ability to give rise to many cell types, whereas a pluripotent stem cell can give rise to all types.

• Muscle Development

  • Human embryonic stem cells are pluripotent; that is, they can differentiate into any of the cell types present in the adult human, and into any of the intermediate progenitor cell types that eventually turn into the adult cell lines. hESCs are also immortal: they can divide and grow in number indefinitely, without undergoing either differentiation or cellular aging (cellular senescence).

• Development of the Immune System

  • This model of lymphopoiesis had the virtue of relative simplicity and agreement with nomenclature and terminology; also, it is essentially valid for the favorite lab animal, the mouse. pHSC pluripotent, self-renewing, hematopoietic stem cells give rise to MPP multipotent progenitors (these give rise to ELP, or PRO, Prolymphocytes); early lymphoid progenitors; and finally to the CLP Common lymphoid progenitor, a cell type fully committed to the lymphoid lineage. pHSC, MPP and ELP cells are not fully committed to the lymphoid lineage because if one is removed to a different location, it may differentiate into non-lymphoid progeny.

• Overview of Cancer

  • Germ cell tumor: Cancers derived from pluripotent cells, most often presenting in the testicle or the ovary (seminoma and dysgerminoma, respectively).