hydrophobic
Biology
(adjective)
Lacking an affinity for water; unable to absorb, or be wetted by water, "water-fearing."
(adjective)
lacking an affinity for water; unable to absorb, or be wetted by water
Chemistry
Examples of hydrophobic in the following topics:
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Hydrophilic and Hydrophobic Colloids
- Hydrocolloids are stable suspensions of hydrophilic molecules; emulsions are suspensions of hydrophobic molecules that need stabilization.
- A hydrophobic colloid, or emulsion, is defined as a colloid system where the particles are hydrophobic polymers.
- Since the colloid does not interact with the aqueous solvent, hydrophobic colloids are inherently unstable and generally do not form spontaneously.
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Water’s Solvent Properties
- Oils, fats, and certain organic solvents do not dissolve in water because they are hydrophobic.
- Water is a poor solvent, however, for hydrophobic molecules such as lipids.
- Nonpolar molecules experience hydrophobic interactions in water: the water changes its hydrogen bonding patterns around the hydrophobic molecules to produce a cage-like structure called a clathrate.
- Thermodynamically, such a large decrease in entropy is not spontaneous, and the hydrophobic molecule will not dissolve.
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Fluid Mosaic Model
- Hydrophobic, or water-hating molecules, tend to be non-polar.
- When placed in water , hydrophobic molecules tend to form a ball or cluster.
- In contrast, the middle of the cell membrane is hydrophobic and will not interact with water.
- This type of protein has a hydrophilic region or regions, and one or several mildly hydrophobic regions.
- This phospholipid molecule is composed of a hydrophilic head and two hydrophobic tails.
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Signaling Molecules
- Small hydrophobic ligands can directly diffuse through the plasma membrane and interact with internal receptors.
- Other hydrophobic hormones include thyroid hormones and vitamin D.
- In order to be soluble in blood, hydrophobic ligands must bind to carrier proteins while they are being transported through the bloodstream.
- Because these molecules are small and hydrophobic, they can diffuse directly across the plasma membrane into the cell, where they interact with internal receptors.
- Compare and contrast the different types of signaling molecules: hydrophobic, water-soluble, and gas ligands
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Selective Permeability
- The hydrophobic and hydrophilic regions of plasma membranes aid the diffusion of some molecules and hinder the diffusion of others.
- Recall that plasma membranes are amphiphilic; that is, they have hydrophilic and hydrophobic regions.
- Lipid-soluble material with a low molecular weight can easily slip through the hydrophobic lipid core of the membrane.
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The Plasma Membrane and the Cytoplasm
- A single phospholipid molecule consists of a polar phosphate "head," which is hydrophilic, and a non-polar lipid "tail," which is hydrophobic.
- Unsaturated fatty acids result in kinks in the hydrophobic tails.
- The hydrophobic tails associate with one another, forming the interior of the membrane.
- The phospholipids are tightly packed together, while the membrane has a hydrophobic interior.
- The hydrophobic tails associate with one another, forming the interior of the membrane.
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Phospholipids
- A phospholipid is an amphipathic molecule which means it has both a hydrophobic and a hydrophilic component.
- The lipid tails, on the other hand, are uncharged, nonpolar, and hydrophobic, or "water fearing."
- A hydrophobic molecule repels and is repelled by water.
- The formation of a micelle is a response to the amphipathic nature of fatty acids, meaning that they contain both hydrophilic and hydrophobic regions.
- The hydrophobic tails associate with one another, forming the interior of the membrane.
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Bile
- The bile salts are ionically charged, with a hydrophobic end and a hydrophillic end.
- When exposed to water mixed with fat, like in the small intestine, the bile salts congregate around a fat droplet, with their hydrophobic side pointing towards the fat and their hydrophillic side pointing towards the water .
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Salt Formation
- Carboxylic acids and salts having alkyl chains longer than six carbons exhibit unusual behavior in water due to the presence of both hydrophilic (CO2) and hydrophobic (alkyl) regions in the same molecule.
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Surface Tension
- Large contact angles are present on hydrophobic surfaces.
- The leaf is a hydrophobic surface.