bioinformatics

Examples of bioinformatics in the following topics:

• Bioinformatic Analyses and Gene Distributions

  • Bioinformatics is the study of methods for storing, retrieving and analyzing biological data.
  • Important sub-disciplines within bioinformatics and computational biology include:
  • The primary goal of bioinformatics is to increase the understanding of biological processes.
  • Gene Ontology, or GO, is a major bioinformatics initiative to unify the representation of gene and gene product attributes across all species.
  • Assembly of the human genome is one of the greatest achievements of bioinformatics

• Crystallographic Analysis

  • .), purification of recombinant proteins (such as chromatography of affinity and gel filtration), enzymatic tests and inhibition measurement (spectrophotometry), crystallization, x-rays crystallography and structural analysis, interactions determination (microcalorimetry, fluorescence, BIAcore), conformational analyses (circular dichroism, ultracentrifugation, light scattering), modifications analysis (mass spectrometry), bioinformatics, and molecular modelisation.

• Annotating Genomes

  • Since the 1980's, molecular biology and bioinformatics have created the need for DNA annotation.

• Detecting Uncultured Microorganisms

  • Advances in bioinformatics, refinements of DNA amplification, and the proliferation of computational power have greatly aided the analysis of DNA sequences recovered from environmental samples.

• The Degradation of Synthetic Chemicals in Soils and Water

  • In recent years, advances in genomics, proteomics, and bioinformatics studies of environmental microorganisms have revealed a tremendous potential in metabolic pathways.

• Metagenomics

  • Advances in bioinformatics, refinements of DNA amplification, and the proliferation of computational power have greatly aided the analysis of DNA sequences recovered from environmental samples, This allows the adaptation of shotgun sequencing to metagenomic samples.

• Homologous Structures

  • This is a common problem in bioinformatics; when genomes of different species have been sequenced and homologous genes have been found, one can not immediately conclude that these genes have the same or similar function, as they could be paralogs whose function has diverged.