Examples of allosteric site in the following topics:
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- In noncompetitive inhibition, an inhibitor molecule binds to the enzyme at a location other than the active site (an allosteric site).
- In noncompetitive allosteric inhibition, inhibitor molecules bind to an enzyme at the allosteric site.
- However, allosteric inhibitors are not the only molecules that bind to allosteric sites.
- They bind to an allosteric site which induces a conformational change that increases the affinity of the enzyme's active site for its substrate.
- Allosteric inhibitors modify the active site of the enzyme so that substrate binding is reduced or prevented.
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- Antagonists mediate their effects by binding to the active site or to allosteric sites on receptors, or they may interact at unique binding sites not normally involved in the biological regulation of the receptor's activity.
- The term "non-competitive antagonism" (sometimes called non-surmountable antagonists) can be used to describe two distinct phenomena: one in which the antagonist binds to the active site of the receptor, and one in which the antagonist binds to an allosteric site of the receptor.
- The second form of "non-competitive antagonists" act at an allosteric site.
- These antagonists bind to a distinctly separate binding site from the agonist, exerting their action to that receptor via the other binding site.
- Uncompetitive antagonists differ from non-competitive antagonists in that they require receptor activation by an agonist before they can bind to a separate allosteric binding site.
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- A number of enzymes involved in each of the pathways (in particular, the enzyme catalyzing the first committed reaction of the pathway) are controlled by attachment of a molecule to an allosteric (non-active) site on the protein.
- This site has an effect on the enzyme's activity, often by changing the conformation of the protein.
- These regulators, known as allosteric effectors, may increase or decrease enzyme activity, depending on the prevailing conditions, altering the steric structure of the enzyme, usually affecting the configuration of the active site.
- The attachment of a molecule to the allosteric site serves to send a signal to the enzyme, providing feedback.
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- Phage display technology is advantageous in many applications including selection of inhibitors for the active and allosteric sites of enzymes, receptor agonists and antagonists, and G-protein binding modulatory peptides.
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- ., a ligand) such as a neurotransmitter.The binding site of endogenous ligands on LGICs protein complexes are normally located on a different portion of the protein (an allosteric binding site) from where the ion conduction pore is located.The ion channel is regulated by a ligand and is usually very selective to one or more ions such as Na+, K+, Ca2+, or Cl-.
- It consists of a pentamer of protein subunits, with two binding sites for acetylcholine, which, when bound, alter the receptor's configuration and cause an internal pore to open.
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- Two cAMP molecules bind dimeric CAP with negative cooperativity and function as allosteric effectors by increasing the protein's affinity for DNA.
- In these operons, a CAP-binding site is located upstream of the RNA-polymerase-binding site in the promoter.
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- Each hemoglobin molecule contains four iron-binding heme groups, which are the site of oxygen (O2) binding.
- The binding process of oxygen is a cooperative process because hemoglobin bound oxygen causes a gradual increases in oxygen binding affinity until all binding sites are on the hemoglobin molecule are filled.
- However, because of allosteric effects on the hemoglobin molecule, the binding of carbon dioxide decreases the amount of oxygen that is bound for a given partial pressure of oxygen.
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- It is allosterically stimulated by NADP+.
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- These are all the credible, well-established canned hosting sites that I know about as of early 2013.
- Again, en.wikipedia.org/wiki/Comparison_of_open_source_software_hosting_facilities has a good comparison of canned hosting sites.
- Instead, this appendix describes the canned hosting sites that I see being used most often by open source projects.
- I include both proprietary sites, i.e., sites for which the source code behind the service is proprietary, and open source ones, i.e., those for which full source code is available under a free license.
- In general, new open source projects should choose one of the sites below, unless they have some special reason to use a different site (e.g., Debian GNU/Linux projects might prefer alioth.debian.org, and Free Software Foundation projects might choose savannah.gnu.org).
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- A web site, obviously — but the full answer is a little more complicated than that.
- The collaboration site would have the code repository, bug tracker, development wiki, links to development mailing lists, etc.
- The two sites should link to each other, and in particular it's important that the user-facing site make it clear that the project is open source and where the open source development activity can be found.
- (As of August 2013, a good example of a project with separate but cross-linked primary and developer sites is the Ozone Widget Framework: compare their main user-facing site at ozoneplatform.org with their development area at github.com/ozoneplatform/owf. ).
- In the past, many projects set up the developer site and infrastructure themselves.