Pharmacology

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Pharmacology is the study of how drugs interact with living organisms to produce a change in function.[1] If substances have medicinal properties, they are considered pharmaceuticals. The field encompasses drug composition and properties, interactions, toxicology, therapy, and medical applications and antipathogenic capabilities. Pharmacology is not synonymous with pharmacy, though in common usage the two are at times confused. Pharmacology deals with how drugs interact within biological systems to affect function, while pharmacy is a medical science concerned with the safe and effective use of medicines.

The word Pharmacology comes from the Greek: pharmakon (φάρμακον) meaning drug, and lego (λέγω) to tell (about). Early pharmacologists focused on natural substances, mainly plant extracts. Pharmacology developed in the 19th century as a new biomedical science that applied the principles of scientific experimentation to therapeutic contexts.[2]

Contents

  • 1 Divisions
  • 2 Scientific background
  • 3 Medicine development and safety testing
  • 4 Drug legislation and safety
  • 5 Education
  • 6 See also
  • 7 Footnotes
  • 8 External links

[edit] Divisions

Pharmacology as a chemical science is practiced by pharmacologists. Subdisciplines include

[edit] Scientific background

The study of chemicals requires intimate knowledge of the biological system affected. With the knowledge of cell biology and biochemistry increasing, the field of pharmacology has also changed substantially. It has become possible, through molecular analysis of receptors, to design chemicals that act on specific cellular signaling or metabolic pathways by affecting sites directly on cell-surface receptors (which modulate and mediate cellular signaling pathways controlling cellular function).

A chemical has, from the pharmacological point-of-view, various properties. Pharmacokinetics describes the effect of the body on the chemical (e.g. half-life and volume of distribution), and pharmacodynamics describes the chemical's effect on the body (desired or toxic).

When describing the pharmacokinetic properties of a chemical, pharmacologists are often interested in ADME:

Medication is said to have a narrow or wide therapeutic index or therapeutic window. This describes the ratio of desired effect to toxic effect. A compound with a narrow therapeutic index (close to one) exerts its desired effect at a dose close to its toxic dose. A compound with a wide therapeutic index (greater than five) exerts its desired effect at a dose substantially below its toxic dose. Those with a narrow margin are more difficult to dose and administer, and may require therapeutic drug monitoring (examples are warfarin, some antiepileptics, aminoglycoside antibiotics). Most anti-cancer drugs have a narrow therapeutic margin: toxic side-effects are almost always encountered at doses used to kill tumours.


[edit] Medicine development and safety testing

Development of medication is a vital concern to medicine, but also has strong economical and political implications. To protect the consumer and prevent abuse, many governments regulate the manufacture, sale, and administration of medication. In the United States, the main body that regulates pharmaceuticals is the Food and Drug Administration and they enforce standards set by the United States Pharmacopoeia. In the European Union, the main body that regulates pharmaceuticals is the EMEA and they enforce standards set by the European Pharmacopoeia.

If the structure of a medicine is altered slightly, this will slightly alter the medicine's properties. This means when a useful activity has been identified, chemists will make many similar compounds called analogues, to attempt and maximise the beneficial effects. This development phase can take up to 3 years and is expensive.[3]

These new analogues need to be developed. It needs to be determined how safe the medicine is for human consumption, its stability in the human body and the best form for dispensing, like tablet or aerosol. After extensive testing, which can take up to 6 years the new medicine is ready for marketing.[3]

As a result of the long time required to develop analogues and test a new medicine and the fact that of every 5000 potential new medicines typically only one will ever reach the open market, this is an expensive way of doing things, costing millions of dollars. To recoup this outlay pharmaceutical companies may do a number of things:[3]

[edit] Drug legislation and safety

In the United States, the Food and Drug Administration (FDA) is responsible for creating guidelines for the approval and use of drugs. The FDA requires that all approved drugs fulfill two requirements:

  1. The drug must be found to be effective against the disease for which it is seeking approval.
  2. The drug must meet safety criteria by being subject to extensive animal and controlled human testing.

Gaining FDA approval usually takes several years to attain. Testing done on animals must be extensive and must include several species to help in the evaluation of both the effectiveness and toxicity of the drug. The dosage of any drug approved for use is intended to fall within a range in which the drug produces a therapeutic effect or desired outcome.[1]

The safety and effectiveness of prescription drugs in the U.S. is regulated by the federal Prescription Drug Marketing Act of 1987.

The Medicines and Healthcare products Regulatory Agency (MHRA) has a similar role in the UK.


[edit] Education

The study of pharmacology is offered in many universities worldwide.