depopulation
(noun)
The act of reducing a population; the destruction or expulsion of inhabitants.
Examples of depopulation in the following topics:
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Disease in the New World
- European exploration and invasion of the Americas brought with them many foreign diseases, causing widespread depopulation among indigenous cultures.
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Changes in American Indian Life
- Smallpox epidemics in 1780–1782, and 1837–1838, brought devastation and drastic depopulation among the Plains Indians.