Concept
Version 10
Created by Boundless
Hormone Receptors
![Example hormone receptor](../../../../../../../../../figures.boundless-cdn.com/152/full/ii-nuclear-receptor-action.jpg)
Example hormone receptor
The thyroid hormone receptor (TR) heterodimerized to the RXR. In the absence of a ligand, the TR is bound to a corepressor protein. Ligand binding to the TR causes a dissociation of co-repressor and recruitment of co-activator proteins, which in turn recruit additional proteins (such as RNA polymerase) that are responsible for the transcription of downstream DNA into RNA, and eventually into protein that results in a change in cell function.
This is a diagram of a hormone passing into a nuclear envelope, binding to a receptor, then leaving the nucelar envelope with changed cell function. The example is of a thyroid hormone receptor (TR) heterodimerized to the RXR. In the absence of a ligand, the TR is bound to a corepressor protein. Ligand binding to the TR causes a dissociation of co-repressor and recruitment of co-activator proteins, which in turn recruit additional proteins (such as RNA polymerase) that are responsible for the transcription of downstream DNA into RNA, and eventually into protein that results in a change in cell function.
Source
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"Type ii nuclear receptor action."
http://commons.wikimedia.org/wiki/File:Type_ii_nuclear_receptor_action.png
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