uncoating

Examples of uncoating in the following topics:

• Antiviral Agents that Prevent Virus Uncoating or Release

  • Another drug target is the uncoating step during viral infection.
  • Uncoating is the process of capsid disintegration, which leads to the release of the genomic material.
  • It is believed that such drugs prevent the virus from uncoating by blocking the proteins on the capsid responsible for uncoating, such as ion channel proteins.

• Neutralization Reaction

  • It may interfere with virion binding to receptors, block uptake into cells, prevent uncoating of the genomes in endosomes, or cause aggregation of virus particles.

• Virus Attachment and Genome Entry

  • There are six basic stages in the life cycle of viruses: attachment, penetration, uncoating, replication, assembly of viral particles, and release.

• Medical Importance of Viruses

  • Once inside a cell, all viruses must uncoat, replicate, and transcribe their genomes, and then repackage their genomes into viral progeny that are released from cells.

• Viral Replication and Gene Expression

  • Uncoating of the viral RNA is mediated by receptor-dependent destabilization of the virus capsid (2).

• General Features of Virus Replication

  • Uncoating is a process in which the viral capsid is removed: This may be by degradation by viral or host enzymes or by simple dissociation.

• Steps of Virus Infections

  • Most productive viral infections follow similar steps in the virus replication cycle: attachment, penetration, uncoating, replication, assembly, and release .

• Replication of Double-Stranded DNA Viruses of Animals

  • Prior to genome replication, the processes of viral attachment, entry and uncoating occur.