ATP citrate lyase

(noun)

ATP citrate lyase is an enzyme that represents an important step in fatty acid biosynthesis. This step in fatty acid biosynthesis occurs because ATP citrate lyase is the link between the metabolism of carbohydrates (which causes energy) and the production of fatty acids.

Related Terms

Examples of ATP citrate lyase in the following topics:

  • The Reverse TCA Cycle

    • The enzymes, unique to reverse TCA, that function in catalyzing these reactions include: ATP citrate lyase, 2-oxoglutarate:ferredoxin oxidoreductase, and pyruvate:ferredoxin oxidoreductase.
    • ATP citrate lyase is one of the key enzymes that function in reverse TCA.
    • ATP citrate lyase is the enzyme responsible for cleaving citrate into oxaloacetate and acetyl CoA.
    • 8) ATP citrate lyase is then used to convert citrate to oxaloacetate and acetyl CoA (ATP is hydrolyzed to ADP and Pi).
    • List the enzymes and function that are unique to the reverse TCA cycle (ATP citrate lyase; 2-oxoglutarate:ferredoxin oxidoreductase; pyruvate:ferredoxin oxidoreductase)

  • Citric Acid Cycle

    • If ATP is in short supply, the rate increases.
    • Citrate loses one water molecule and gains another as citrate is converted into its isomer, isocitrate.
    • This form produces ATP.
    • One GTP or ATP is also made in each cycle.
    • Through a series of steps, citrate is oxidized, releasing two carbon dioxide molecules for each acetyl group fed into the cycle.

  • Control of Catabolic Pathways

    • High levels of ATP, citrate, or a lower, more acidic pH decrease the enzyme's activity.
    • An increase in citrate concentration can occur because of a blockage in the citric acid cycle.
    • Pyruvate kinase is also regulated by ATP (a negative allosteric effect).
    • Greater ATP consumption by a cell is indicated by a buildup of ADP.
    • As ATP usage decreases, the concentration of ADP decreases: ATP begins to build up in the cell.