ATP-binding cassette (ABC) domain

(noun)

The ATP-binding cassette (ABC) family is a group of proteins which bind and hydrolyse ATP in order to transport substances across cellular membranes.

Related Terms

Examples of ATP-binding cassette (ABC) domain in the following topics:

  • ABC Transporters

    • ABC transporters are a protein superfamily that all have an ATP binding cassette and transport substances across membranes.
    • ATP-binding cassette transporters (ABC-transporters) are members of a protein superfamily that is one of the largest and most ancient families with representatives in all extant phyla from prokaryotes to humans.
    • ABC transporters are transmembrane proteins that utilize the energy of adenosine triphosphate (ATP) hydrolysis to carry out certain biological processes including translocation of various substrates across membranes and non-transport-related processes such as translation of RNA and DNA repair.
    • Proteins are classified as ABC transporters based on the sequence and organization of their ATP-binding cassette (ABC) domain(s).
    • Proposed mechanism of transport for ABC importers.

  • Generalized Recombination and RecA

    • Homologous recombination is conserved across all three domains of life as well as viruses.
    • The RecB subunit also has a nuclease domain, which cuts the single strand of DNA that emerges from the unzipping process.
    • This model is based on reactions of DNA and RecBCD with Mg2+ ions in excess over ATP.
    • Step 1: RecBCD binds to a DNA double strand break.
    • Step 2: RecBCD initiates unwinding of the DNA duplex through ATP-dependent helicase activity.