Concept
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Intracellular Hormone Receptors
Hormone regulation of gene expression
An intracellular nuclear receptor (NR) is located in the cytoplasm bound to a heat shock protein (HSP). Upon hormone binding, the receptor dissociates from the heat shock protein and translocates to the nucleus. In the nucleus, the hormone-receptor complex binds to a DNA sequence called a hormone response element (HRE), which triggers gene transcription and translation. The corresponding protein product can then mediate changes in cell function.
Source
Boundless vets and curates high-quality, openly licensed content from around the Internet. This particular resource used the following sources:
"OpenStax College, How Hormones Work. October 17, 2013."
http://cnx.org/content/m44768/latest/Figure_37_02_01.png
OpenStax CNX
CC BY 3.0.